CAS:51868-95-2|1-(Benzo[b]thien-2-yl)ethanol

Catalogue Number:B206665
Chemical Name:1-(Benzo[b]thien-2-yl)ethanol
Synonyms:2-(1-Hydroxyethyl)benzothiophene; 2-(1-Hydroxyethyl)thianaphthene; α-Methyl-2-benzo[b]thiophenemethanol; α-Methylbenzo[b]thiophene-2-methanol
CAS Number:51868-95-2
Molecular Formula:C₁₀H₁₀OS
Molecular Weight:178.25
Category:Research Tools; Standards; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-(Benzo[b]thien-2-yl)ethanol is an intermediate used to prepare amino sugar and related sugar derivatives of indolopyrrolocarbazoles as antitumors. It is also an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Zileuton is used as an antiasthmatic.
References:Saulnier, M., et al.: PCT Int. Appl. (1998), WO 9807433 A1 19980226; Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991); Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1992); McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)
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