CAS:103962-10-3|2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one

Catalogue Number:B200055
Chemical Name:2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one
Synonyms:2-Bromo-1-(4-trifluoromethoxyphenyl)ethanone; 2-Bromo-4′-(trifluoromethoxy)acetophenone; 4-(Trifluoromethoxy)phenacyl bromide
CAS Number:103962-10-3
Molecular Formula:C₉H₆BrF₃O₂
Appearance:White to Off-White Solid
Melting Point:54 – 55°C
Molecular Weight:283.04
Storage:-20°C, Inert atmosphere
Solubility:Chloroform (Sparingly), Methanol (Slightly)
Category:Building Blocks; Miscellaneous;
Applications:2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one is an intermediate used to prepare aminothiazoles as therapeutic leads for prion diseases. It is also used in the synthesis of pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
References:Gallardo-Godoy, A., et al.: J. Med. Chem., 54, 1010 (2011); Keith, J., et al.: Bioorg. Med. Chem. Lett., 17, 2603 (2007)
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