Catalogue Number:B199420
Chemical Name:N-((1-(2-(3-(tert-Butyl)ureido)ethyl)-4-(hydroxymethyl)piperidin-4-yl)methyl)-3,5-dichlorobenzamide
Synonyms:3,5-Dichloro-N-[[1-[2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]ethyl]-4-(hydroxymethyl)-4-piperidinyl]methyl]benzamide
CAS Number:1416984-93-4
Molecular Formula:C₂₁H₃₂Cl₂N₄O₃
Molecular Weight:459.41
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-((1-(2-(3-(tert-Butyl)ureido)ethyl)-4-(hydroxymethyl)piperidin-4-yl)methyl)-3,5-dichlorobenzamide is discovered as a potential peripheral T-type calcium channel inhibitor, its hERG and CYP 2D6 inhibition, microsomal stability, and pharmacokinetics and heart rate reduction in dogs.
References:Giordanetto, F., et al.:Bioorg. Med. Chem. Lett. 23, 119 (2013)
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