Catalogue Number:B189750
Chemical Name:9-O-Benzenesulfonyl (±)-Tetrahydropalmatrubine
Synonyms:5,8,13,13a-Tetrahydro-2,3,10-trimethoxy-6H-dibenzo[a,g]quinolizin-9-ol, , 9-Benzenesulfonate
CAS Number:1095271-88-7
Molecular Formula:C₂₆H₂₇NO₆S
Molecular Weight:481.56
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:9-O-Benzenesulfonyl (±)-Tetrahydropalmatrubine is a derivative of Berberine (B318150), which is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. This compound also has been used to modulate lipid levels.
References:Zhang, X. et al.: Cancer Res., 70, 9895 (2010); Lin, H.L. et al.: Cancer 85, 1937(1999); Schumacher, M.A. et al.: Science, 294, 2158 (2001); Fukuda, K. et al.: J. Ethno., 66, 227(1999);
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