3-[[2-(4-Chlorophenyl)-2-cyclopentyl-2-hydroxyacetyl]oxy]-1,1-dimethylpyrrolidinium Bromide

Chemical Name:3-[[2-(4-Chlorophenyl)-2-cyclopentyl-2-hydroxyacetyl]oxy]-1,1-dimethylpyrrolidinium Bromide
Synonyms:Glycopyrrolate Bromide Impurity I
CAS Number:1404453-68-4
Alternate CAS #:Free base: 1404617-94-2
Molecular Formula:C₁₉H₂₇BrClNO₃
Molecular Weight:432.78
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-[[2-(4-Chlorophenyl)-2-cyclopentyl-2-hydroxyacetyl]oxy]-1,1-dimethylpyrrolidinium Bromide, is a Glycopyrronium Bromide (G656980) impurity, which has a broad pharmacology and medical applications. Glycopyrronium blocks muscarinic receptors, thus inhibiting cholinergic transmission. It is also used to reduce excessive saliva (sialorrhea).It also decreases acid secretion in the stomach and so may be used for treating stomach ulcers, in combination with other medications. Also, It can be used in treating asthma and COPD.
References:Haddad E.B., et al.: Br. J. Pharma., 127, 413 (1999); Bajaj, V., et al.: Br. J. Dermatol., 157, 118 (2007); Miler, RJ., et al.: Arch. Pediatr. Adolesc. Med., 154, 1214 (2000); Kaltiala, E., et al.: J. Pharm. Pharmacol., 26, 352 (1974), Kongsrud, F., et al.: Acta Anaesthesiol. Scand., 26, 620 (1982),
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