Catalogue Number:A105020
Chemical Name:Abacavir 5’-Phosphate
Synonyms:(1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
Impurity:Abacavir – In House Impurity:CAS Number:136470-77-4
Molecular Formula:C₁₄H₁₉N₆O₄P
Appearance:White Solid
Melting Point:189-194°C (dec.)
Molecular Weight:366.31
Storage:-20°C
Solubility:Methanol, Water
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Abacavir 5’-Phosphate (Abacavir – In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2′-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References:(1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012)
(2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)
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