Catalogue Number:D242600
Chemical Name:5′-Deoxy-5′-(methylthio)adenosine
Synonyms:5′-S-Methyl-5′-thioadenosine; 5′-(Methylthio)-5′-deoxyadenosine; 5′-(Methylthio)adenosine; 5′-Deoxy(methylthio)adenosine; 5′-S-Methyl-5′-thioadenosine; 5′-S-Methylthioadenosine; NSC 335422; Vitamin L2; 1-(6-Amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β-D-ribofuranose;
CAS Number:2457-80-9
Molecular Formula:C₁₁H₁₅N₅O₃S
Appearance:White to Off-White Solid
Melting Point:205-210ºC
Molecular Weight:297.33
Storage:4°C
Solubility:DMF (Sparingly), DMSO (Slightly), Methanol (Slightly)
Category:Standards; Carbohydrates and Oligosaccharides;
Applications:5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References:Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),
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