CAS:1616340-68-1|5-​[[[(2,​4-​Difluorophenyl)​methyl]​amino]​carbonyl]​-​1-​(2,​2-​dimethoxyethyl)​-​1,​4-​dihydro-​3-​methoxy-​4-​oxo-2-pyridinecarboxylic Acid Methyl Ester

Catalogue Number:D161635
Chemical Name:5-​[[[(2,​4-​Difluorophenyl)​methyl]​amino]​carbonyl]​-​1-​(2,​2-​dimethoxyethyl)​-​1,​4-​dihydro-​3-​methoxy-​4-​oxo-2-pyridinecarboxylic Acid Methyl Ester
CAS Number:1616340-68-1
Molecular Formula:C₂₀H₂₂F₂N₂O₇
Molecular Weight:440.39
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-​[[[(2,​4-​Difluorophenyl)​methyl]​amino]​carbonyl]​-​1-​(2,​2-​dimethoxyethyl)​-​1,​4-​dihydro-​3-​methoxy-​4-​oxo-2-pyridinecarboxylic Acid Methyl Ester is an intermediate in the synthesis of Cabotegravir-d3 (C050102), which is the labelled form of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.
References:Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)
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