Catalogue Number:C990413
Chemical Name:(1S,2S)-1,2-Cyclopropanedicarboxylic Acid 1,2-Diethyl Ester
Synonyms:(1S,2S)-Diethyl cyclopropane-1,2-dicarboxylate
CAS Number:889461-57-8
Molecular Formula:C₉H₁₄O₄
Appearance:Pale Yellow Oil
Molecular Weight:186.21
Storage:-20°C
Solubility:Dichloromethane
Category:Standards; Miscellaneous;
Applications:(1S,2S)-1,2-Cyclopropanedicarboxylic Acid 1,2-Diethyl Ester is an intermediate in synthesizing (O846925), (2S,3S)-2,3-Oxiranedicarboxylic Acid Monoethyl Ester is used in the synthesis of aza-peptidyl inhibitors of lysosomal asparaginyl endopeptidase, legumain. Also used in the synthesis of irreversible epidermal growth factor receptor inhibitors and probes for cathespins.
References:Lee, J. et al.: Bioorg. Med. Chem. Lett., 22, 1340 (2012); Carmi, C. et al.: J. Med. Chem., 53, 2038 (2010); Hillaert, U. et al.: Angew. Chem. Int. Ed., 48, 1629 (2009);
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