Chemical Name:GGTI-2147
Synonyms:N-[4-[(1H-Imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-L-leucine Methyl Ester; GGTI 2147
CAS Number:191102-87-1
Molecular Formula:C₂₈H₃₀N₄O₃
Molecular Weight:470.56
Category:Research Tools;
Applications:GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.
References:Chang, S. et al.: J. Lipid. Res., 53, 1176 (2012); Veluthakal, R. et al.: Diabetes., 56, 204 (2007)
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