(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile

Chemical Name:(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile
CAS Number:1037559-82-2
Molecular Formula:C₈H₁₂N₂
Molecular Weight:136.19
Category:Building Blocks; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile is a boceprevir bicyclic [3.1.0]​proline intermediate, a key structural feature in the preparation of Boceprevir Merck’s drug for the treatment of hepatitis C.
References:Li, T., et al.: J. Am. Chem. Soc., 134, 6467 (2012)
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