5-[[[(2,4-Difluorophenyl)methyl]amino]carbonyl]-1,4-dihydro-3-hydroxy-4-oxo-1-[(tetrahydro-4-methyl-2H-1,3-oxazin-2-yl)methyl]-2-pyridinecarboxylic Acid

Chemical Name:5-[[[(2,4-Difluorophenyl)methyl]amino]carbonyl]-1,4-dihydro-3-hydroxy-4-oxo-1-[(tetrahydro-4-methyl-2H-1,3-oxazin-2-yl)methyl]-2-pyridinecarboxylic Acid
CAS Number:1800247-07-7
Molecular Formula:C₂₀H₂₁F₂N₃O₆
Molecular Weight:437.39
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-[[[(2,4-Difluorophenyl)methyl]amino]carbonyl]-1,4-dihydro-3-hydroxy-4-oxo-1-[(tetrahydro-4-methyl-2H-1,3-oxazin-2-yl)methyl]-2-pyridinecarboxylic Acid is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor.
References:Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);
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