The Last One Mile in Drug Development
Protein-protein interactions (PPI) are physical and chemical contacts between two or more protein molecules. As a fundamental aspect of almost all biological processes, any interference of the sophisticated PPI network could result in potential physiological disorder or disease. Although some PPI networks have been well-established for their roles in tumor development and therefore have been […]
DNA-encoded library (DEL) technology represents a revolutionary method in drug discovery. Unlike conventional approaches, DEL enables unparalleled exploration of chemical space, leading to the rapid identification of novel potent compounds. Although the importance of DEL screening in hit discovery has been well recognized, the power of DEL technology in compound optimization has only been appreciated […]
Although many covalent drugs were serendipitously discovered historically, covalent inhibitors were in general discouraged due to the concerns over their interference with biological assays and potential lack of selectivity. Over the past decades, rational design of covalent inhibitors has gained traction and garnered increased interest, particularly due to their stronger potency, prolonged target engagement, increased […]
The advancement of DNA Encoded Library (DEL) technology has been significant in recent decades. Beyond its conventional role in small molecule drug discovery, its integration into emerging fields has begun to garner increased interest. This can be attributed to its large chemical space, abundant Structure-Signal Relationship (SSR) data, and inherent DNA conjugation properties. In this […]
Vernalis (R&D) Limited (“Vernalis”), a wholly owned subsidiary of HitGen Inc., and C4X Discovery (“C4XD”) are pleased to announce a collaboration to identify modulators of an undisclosed high-value target involved in inflammatory disease. Within the collaboration, Vernalis will use its state-of-the-art protein science and Hit ID platforms to produce the target protein and to identify […]
Catalogue Number:B374980Chemical Name:4-(Benzyloxy)-6-bromopyridin-2-olSynonyms:6-Bromo-4-(phenylmethoxy)- 2-pyridinoneCAS Number:1956382-50-5Molecular Formula:C₁₂H₁₀BrNO₂Molecular Weight:280.12Category:Standards;Applications:4-(Benzyloxy)-6-bromopyridin-2-ol is a useful research chemical compound.To ensure the stability of our products, the efficient express delivery service will be used. We also guarantee that the products will be shipped in the box with layers of tapes to protect them against damage. The extremely low temperature products will be […]
Catalogue Number:B373495Chemical Name:3,3′-Bi-p-anisidineSynonyms:6,6′-Dimethoxy-[1,1′-biphenyl]-3,3′-diamineCAS Number:23131-04-6Molecular Formula:C₁₄H₁₆N₂O₂Appearance:Off-White to Pale Brown SolidMelting Point:>157°C (dec.)Molecular Weight:244.29Storage:4°C, HygroscopicSolubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)StabilityAir SensitiveCategory:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:3,3′-Bi-p-anisidine is an p-acetamidopheno (A161220) analog that were used to determine peroxidase activities.References:Potter, D.W. et al.: Mol. Pharmacol., 29, 155 (1986); Shiga, M. et al.: Anal. Sci., 11, 195 (1995);To ensure the stability of […]
Catalogue Number:B373480Chemical Name:BI 6015Synonyms:2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole; 2-Methyl-1-[(5-nitro-o-tolyl)sulfonyl]-benzimidazole;CAS Number:93987-29-2Molecular Formula:C₁₅H₁₃N₃O₄SMolecular Weight:331.35Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines.References:Kiselyuk. A., et al.: Chem. Biol., 19, 806 (2012);To ensure the stability […]
Catalogue Number:B372800Chemical Name:BiapenemSynonyms:6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium Inner Salt; Biapenern; Omegacin;CAS Number:120410-24-4Molecular Formula:C₁₅H₁₈N₄O₄SAppearance:White to Off-White SolidMelting Point:>200°C (dec.)Molecular Weight:350.39Storage:-20°CSolubility:Water (Slightly, Heated)Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;Applications:An carbapenem antibacterial.References:Shigemi, A., et al.: Int. J. Antimicrob. Agents, 34, 589 (2009), Miguet, L., et al.: J. Med. Chem., 52, 5926 (2009), Zhao, W., et al.: J. Med. Microbiol., 58, 1080 (2009), Sanbongi, […]
Catalogue Number:B372300Chemical Name:Bialaphos Sodium SaltSynonyms:(2S)-2-Amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine Monosodium Salt; ?-(Hydroxymethylphosphinyl)-L-?-aminobutyryl-L-alanyl-L-alanine Monosodium Salt; Bilanafos Sodium Salt; Herbi-Ace; Herbie; MW 801; SF 1293CAS Number:71048-99-2Alternate CAS #Free Acid: 35597-43-4Molecular Formula:C₁₁H₂₁N₃NaO₆PAppearance:White to Pale Beige SolidMelting Point:>177C (dec.)Molecular Weight:345.26Storage:4°C, HygroscopicSolubility:DMSO (Very Slightly, Heated), Methanol (Slightly, Sonicated), Water (Slightly, SStabilityHygroscopicCategory:Standards; Chiral Molecules;Applications:Bialaphos Sodium Salt is a herbicide.Not a dangerous good if item is […]
